Publicaties
| Marjolein F. Lansbergen, Mark P.G. Dings, Paul Manoukian, Arantza Fariña, Cynthia Waasdorp, Gerrit K.J. Hooijer, Joanne Verheij, Jan Koster, Danny A. Zwijnenburg, Johanna W. Wilmink, Jan Paul Medema, Frederike Dijk, Hanneke W.M. van Laarhoven, Maarten F. Bijlsma
Transcriptome-based classification to predict FOLFIRINOX response in a real-world metastatic pancreatic cancer cohort Translational Research |
Published:
Nov, 2024 |
| Lindsay Angus, Marcel Smid, Saskia M. Wilting, Manouk K. Bos, Neeltje Steeghs, Inge R.H.M. Konings, Vivianne C.G. Tjan-Heijnen, Johanna M.G.H. Van Riel, Agnes J. Van de Wouw, CPCT Consortium, Edwin Cuppen, Martijn P. Lolkema, Agnes Jager, Stefan Sleijfer, John W. M. Martens.
Genomic alterations associated with estrogen receptor pathway activity in metastatic breast cancer have a differential impact on downstream ER signaling Pudmed: https://pubmed.ncbi.nlm.nih.gov/37686693/ |
Published:
Sep 4, 2023 |
| W S van de Geer WS, Ron H J Mathijssen, Job van Riet, Neeltje Steeghs, Mariette Labots, Carla van Herpen, L A Devriese, Vivianne C G Tjan-Heijnen, Emile E Voest, Stefan Sleijfer, John W M Martens, Edwin Cuppen, Harmen J G van de Werken, Sander Bins.
Identifying somatic changes in drug transporters using whole genome and transcriptome sequencing data of advanced tumors. Pubmed https://pubmed.ncbi.nlm.nih.gov/36621142/ |
Published:
Jan 6, 2023 |
| Melinda A Pruis, F H Groenendijk, KS Badloe, Andrea van Puffelen, Debbie Robbrecht, W N M Dinjens, Stefan Sleijfer, Annemarie C Dingemans, J H von der Thüsen, Paul Roepman, Martijn P J K Lolkema
Personalised selection of experimental treatment in patients with advanced solid cancer is feasible using whole-genome sequencing. PubMed https://pubmed.ncbi.nlm.nih.gov/35606463/ |
Published:
May 23, 2022 |
| Pauline A J Mendelaar, Debbie Robbrecht, Maud Rijnders, Ronald de Wit, Vanja de Weerd, Teoman Deger, Hans M Westgeest, Maureen J B Aarts, Jens Voortman, John W M Martens, Astrid A M van der Veldt, J Alberto Nakauma-González, Saskia M Wilting, Martijn Lolkema
Genome-wide aneuploidy detected by mFast-SeqS in circulating cell-free DNA is associated with poor response to pembrolizumab in patients with advanced urothelial cancer PubMed |
Published:
February 18, 2022 |
| J Alberto Nakauma-González, Maud Rijnders, Job van Riet, Michiel S van der Heijden, Jens Voortman, Edwin Cuppen, Niven Mehra, Sandra van Wilpe, Sjoukje F Oosting, L Lucia Rijstenberg, Hans M Westgeest, Ellen C Zwarthoff, Ronald de Wit, Astrid A M van der Veldt, Harmen J G van de Werken, Martijn P J Lolkema, Joost L Boormans
Comprehensive Molecular Characterization Reveals Genomic and Transcriptomic Subtypes of Metastatic Urothelial Carcinoma PubMed |
Published:
January 24, 2022 |
| Luuk J Schipper, Kim Monkhorst, Kris G Samsom, Linda J W Bosch, Petur Snaebjornsson, Hester van Boven, Paul Roepman, Lizet E van der Kolk, Winan J van Houdt, Winette T A van der Graaf, Gerrit A Meijer, Emile E Voest
Clinical Impact of Prospective Whole Genome Sequencing in Sarcoma Patients PubMed |
Published:
January 16, 2022 |
| Noori A M Guman, Roos J van Geffen, Frits I Mulder, Thijs F van Haaps, Vahram Hovsepjan, Mariette Labots, Geert A Cirkel, Filip Y F L de Vos, Albert J Ten Tije, Laurens V Beerepoot, Vivianne C G Tjan-Heijnen, Hanneke W M van Laarhoven, Paul Hamberg, Annelie J E Vulink, Maartje Los, Aeilko H Zwinderman, Bart Ferwerda, Martijn P J K Lolkema, Neeltje Steeghs, Harry R Büller, Pieter W Kamphuisen, Nick van Es
Evaluation of the Khorana, PROTECHT, and 5-SNP scores for prediction of venous thromboembolism in patients with cancer PubMed |
Published:
December 19, 2021 |
| Joris van de Haar, Louisa R Hoes, Paul Roepman, Martijn P Lolkema, Henk M W Verheul, Hans Gelderblom, Adrianus J de Langen, Egbert F Smit, Edwin Cuppen, Lodewyk F A Wessels, Emile E Voest
Limited evolution of the actionable metastatic cancer genome under therapeutic pressure Nat Med |
Published:
September 27, 2021 |
| Job van Riet, Harmen J. G. van de Werken, Edwin Cuppen, Ferry A. L. M. Eskens, Margot Tesselaar, Linde M. van Veenendaal, Heinz-Josef Klümpen, Marcus W. Dercksen, Gerlof D. Valk, Martijn P. Lolkema, Stefan Sleijfer & Bianca Mostert
The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets Nature Communications |
Published:
July 29, 2021 |
| Martijn Simons, Michiel van de Ven, Veerle Coupé, Manuela Joore, Maarten IJzerman, Erik Koffijberg, Geert Frederix, Carin Uyl – De Groot, Edwin Cuppen, Wim van Harten & Valesca Retèl on behalf of the TANGO consortium
Early technology assessment of using whole genome sequencing in personalised oncology Expert Rev Pharmacoeconomics & Outcome Res https://www.tandfonline.com/doi/full/10.1080/14737167.2021.1917386 |
Published:
April 29, 2021 |
| Pauline A.J. Mendelaar, Marcel Smid, Job van Riet, Lindsay Angus, Mariette Labots, Neeltje Steeghs, Mathijs P. Hendriks, Geert A. Cirkel, Johan M. van Rooijen, Albert J. Ten Tije, CPCT Consortium, Martijn P.J.K. Lolkema, Edwin Cuppen, Stefan Sleijfer, John W.M. Martens & Saskia M. Wilting
Whole genome sequencing of metastatic CRC reveals prior treatment effects, metastasis-specific features, and potential clinical actionability Nature Communications |
Published:
January 25, 2021 |
| Luan Nguyen, John W.M. Martens, Arne Van Hoeck & Edwin Cuppen
Pan-cancer landscape of homologous recombination deficiency Nature Communications |
Published:
November 04, 2020 |
| Martijn Simons, Bram Ramaekers, Andrea Peeters, Joanne Mankor, Marthe Paats, Joachim Aerts, Wim van Harten, Valesca Retèl, Manuela Joore
Observed versus modelled lifetime overall survival of targeted therapies and immunotherapies for advanced non-small cell lung cancer patients – A systematic review. Critical Reviews in Oncology/Hematology https://www.sciencedirect.com/science/article/pii/S1040842820301736?dgcid=coauthor |
Published:
September 23, 2020 |
| Thomas BK Watkins, Emilia L Lim, Marina Petkovic, Sergi Elizalde, Nicolai J Birkbak, Gareth A Wilson, David A Moore, Eva Grönroos, Andrew Rowan, Sally M Dewhurst, Jonas Demeulemeester, Stefan C Dentro, Stuart Horswell, Lewis Au, Kerstin Haase, Mickael Escudero, Rachel Rosenthal, Maise Al Bakir, Hang Xu, Kevin Litchfield, Wei Ting Lu, Thanos P Mourikis, Michelle Dietzen, Lavinia Spain, George D Cresswell, Dhruva Biswas, Philippe Lamy, Iver Nordentoft, Katja Harbst, Francesc Castro-Giner, Lucy R Yates, Franco Caramia, Fanny Jaulin, Cécile Vicier, Ian PM Tomlinson, Priscilla K Brastianos, Raymond J Cho, Boris C Bastian, Lars Dyrskjøt, Göran B Jönsson, Peter Savas, Sherene Loi, Peter J Campbell, Fabrice Andre, Nicholas M Luscombe, Neeltje Steeghs, Vivianne CG Tjan-Heijnen, Zoltan Szallasi, Samra Turajlic, Mariam Jamal-Hanjani, Peter Van Loo, Samuel F Bakhoum, Roland F Schwarz, Nicholas McGranahan, Charles Swanton
Pervasive Chromosomal Instability and Karyotype Order In Tumour Evolution Nature |
Published:
September 02, 2020 |
| Cayetano Pleguezuelos-Manzano, Jens Puschhof, Axel Rosendahl Huber, Arne van Hoeck, Henry M. Wood, Jason Nomburg, Carino Gurjao, Freek Manders, Guillaume Dalmasso, Paul B. Stege, Fernanda L. Paganelli, Maarten H. Geurts, Joep Beumer, Tomohiro Mizutani, Reinier van der Linden, Stefan van Elst, Genomics England Research Consortium, Janetta Top, Rob J.L. Willems, Marios Giannakis, Richard Bonnet, Phil Quirke, Matthew Meyerson, Edwin Cuppen, Ruben van Boxtel, Hans Clevers
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. Nature |
Published:
February 27, 2020 |
| Joanne M. Mankor, Marthe S. Paats, Floris H. Groenendijk, Paul Roepman, Winand N. M. Dinjens, Hendrikus J. Dubbink, Stefan Sleijfer, CPCT Consortium, Edwin Cuppen & Martijn P.J.K. Lolkema
Impact of panel design and cut-off on tumour mutational burden assessment in metastatic solid tumour samples British journal of cancer |
Published:
February 25, 2020 |
| Wei Jiao, Gurnit Atwal, Paz Polak, Rosa Karlic, Edwin Cuppen, Alexandra Danyi, Jeroen de Ridder, Carla van Herpen, Martijn P Lolkema, Neeltje Steeghs, Gad Getz, Quaid D Morris, Lincoln D. Stein, PCAWG Pathology & Clinical Correlates Working Grp, ICGC/TCGA Pan-cancer Analysis of Whole Genomes Net
A deep learning system can accurately classify primary and metastatic cancers based on patterns of passenger mutations. Nature Communications |
Published:
February 05, 2020 |
| Lisanne F. van Dessel, Job van Riet, Minke Smits, Yanyun Zhu, Paul Hamberg, Michiel S. van der Heijden, Andries M. Bergman, Inge M. van Oort, Ronald de Wit, Emile E. Voest, Neeltje Steeghs, Takafumi N. Yamaguchi, Julie Livingstone, Paul C. Boutros, John W.M. Martens, Stefan Sleijfer, Edwin Cuppen, Wilbert Zwart, Harmen J.G. van de Werken, Niven Mehra & Martijn P. Lolkema
The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact. Nature Commununications |
Published:
November 20, 2019 |
| Oriol Pich, Ferran Muiños, Martijn Paul Lolkema, Neeltje Steeghs, Abel Gonzalez-Perez, Nuria Lopez-Bigas
The mutational footprints of cancer therapies. Nature Genetics |
Published:
November 18, 2019 |
| Peter Priestley, Jonathan Baber, Martijn P. Lolkema, Neeltje Steeghs, Ewart de Bruijn, Charles Shale, Korneel Duyvesteyn, Susan Haidari, Arne van Hoeck, Wendy Onstenk, Paul Roepman, Mircea Voda, Haiko J. Bloemendal, Vivianne C. G. Tjan-Heijnen, Carla M. L. van Herpen, Mariette Labots, Petronella O. Witteveen, Egbert F. Smit, Stefan Sleijfer, Emile E. Voest & Edwin Cuppen
Pan-cancer whole-genome analyses of metastatic solid tumors. Nature https://www.nature.com/articles/s41586-019-1689-y (October 23, 2020) https://www.biorxiv.org/content/10.1101/2020.01.13.905026v2 (June 19, 2020) |
Published:
October 23, 2019 |
| Christensen S, Van der Roest B, Besselink N, Janssen R, Boymans S, Martens JWM, Yaspo ML, Priestley P, Kuijk E, Cuppen E, Van Hoeck A.
5-Fluorouracil treatment induces characteristic T>G mutations in human cancer. Nature Communications |
Published:
October 08, 2019 |
| Lindsay Angus, Marcel Smid, Saskia M. Wilting, Job van Riet, Arne Van Hoeck, Luan Nguyen, Serena Nik-Zainal, Tessa G. Steenbruggen, Vivianne C.G. Tjan-Heijnen, Mariette Labots, Johanna M.G.H. van Riel, Haiko J. Bloemendal, Neeltje Steeghs, Martijn P. Lolkema, Emile E. Voest, Harmen J.G. van de Werken, Agnes Jager, Edwin Cuppen, Stefan Sleijfer and John W.M. Martens
The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies. Nature Genetics |
Published:
September 30, 2019 |
| D.L. van der Velden, L.R. Hoes, H. van der Wijngaart, J.M. van Berge Henegouwen, E. van Werkhoven, P. Roepman, R.L. Schilsky, W.W.J. de Leng, A.D.R. Huitema, B. Nuijen, P.M. Nederlof, C.M.L. van Herpen, D.J.A. de Groot, L.A. Devriese, A. Hoeben, M.J.A. de Jonge, M. Chalabi, E.F. Smit, A.J. de Langen, N. Mehra, M. Labots, E. Kapiteijn, S. Sleijfer, E. Cuppen, H.M.W. Verheul, H. Gelderblom and E.E. Voest
The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs. Nature |
Published:
September 30, 2019 |
| Daniel L. Cameron, Jonathan Baber, Charles Shale, Anthony T. Papenfuss, Jose Espejo Valle-Inclan, Nicolle Besselink, Edwin Cuppen, Peter Priestley
GRIDSS, PURPLE, LINX: Unscrambling the tumor genome via integrated analysis of structural variation and copy number. bioRxiv 781013 |
Published:
September 25, 2019 |
| Ausems MGEM, Oosterwijk JC, Nielsen M, Lolkema MP, Hoogerbrugge N, Ligtenberg MJL.
Genetic testing in patients with cancer, new developments. Ned Tijdschr Geneeskd. |
Published:
May 20, 2019 |
| Giesbertz NAA, van Harten MH, Bredenoord AL.
A duty of recontact in genetics: context matters. Nature Reviews Genetics |
Published:
April 01, 2019 |
| Kirsten Kübler, Rosa Karlić, Nicholas J. Haradhvala, Kyungsik Ha, Jaegil Kim, Maja Kuzman, Wei Jiao, Sitanshu Gakkhar, Kent W. Mouw, Lior Z. Braunstein, Olivier Elemento, Andrew V. Biankin, Ilse Rooman, Mendy Miller, Wouter R. Karthaus, Christopher D. Nogiec, Edouard Juvenson, Edward Curry, Mari Mino- Kenudson, Leif W. Ellisen, Robert Brown, Alexander Gusev, Cristian Tomasetti, Martijn P. Lolkema, Neeltje Steeghs, Carla van Herpen, Hong-Gee Kim, Hwajin Lee, Kristian Vlahoviček, Bradley E. Bernstein, Charles L. Sawyers, Katherine A. Hoadley, Edwin Cuppen, Amnon Koren, Peter F. Arndt, David N. Louis, Lincoln D. Stein, William D. Foulkes, Paz Polak, Gad Getz, on behalf of the PCAWG Pathology and Clinical Correlates Working Group, and the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Network
Tumor mutational landscape is a record of the pre-malignant state bioRxiv 517565 |
Published:
January 11, 2019 |
| Bijlsma RM, Wouters RHP, Wessels H, May AM, Ausems MGEM, Voest EE, Bredenoord AL.
Managing unsolicited findings in genomics: A qualitative interview study with cancer patients. Psychooncology https://pubmed.ncbi.nlm.nih.gov/29471587/ |
Published:
February 22, 2018 |
| Bijlsma RM, Wessels H, Wouters RHP, May AM, Ausems MGEM, Voest EE, Bredenoord AL.
Cancer patients’ intentions towards receiving unsolicited genetic information obtained using next-generation sequencing. Fam Cancer https://pubmed.ncbi.nlm.nih.gov/28852913/ |
Published:
April 17, 2018 |
| Weeber F, Cirkel GA, Hoogstraat M, Bins S, Gadellaa-van Hooijdonk CGM, Ooft S, van Werkhoven E, Willems SM, van Stralen M, Veldhuis WB, Besselink NJM, Horlings HM, Steeghs N, de Jonge MJ, Langenberg MHG, Wessels LFA, Cuppen EPJG, Schellens JH, Sleijfer S, Lolkema MP, Voest EE.
Predicting clinical benefit from everolimus in patients with advanced solid tumors, the CPCT-03 study. Oncotarget https://pubmed.ncbi.nlm.nih.gov/28903445/ |
Published:
March 8, 2017 |
| Bins S, Cirkel GA, Gadellaa-van Hooijdonk CG, Weeber F, Nijman IJ, Bruggink AH, van Diest PJ, Willems SM, Veldhuis WB, van den Heuvel MM, de Knegt RJ, Koudijs MJ, van Werkhoven E, Mathijssen RH, Cuppen E, Sleijfer S, Schellens JH, Voest EE, Langenberg MH, de Jonge MJ, Steeghs N, Lolkema MP.
Implementation of a Multicenter Biobanking Collaboration for Next-Generation Sequencing-Based Biomarker Discovery Based on Fresh Frozen Pretreatment Tumor Tissue Biopsies. The Oncologist https://theoncologist.onlinelibrary.wiley.com/doi/full/10.1634/theoncologist.2016-0085 |
Published:
January 17, 2017 |
| Rhodé M Bijlsma, Annelien L Bredenoord, Christa G Gadellaa-Hooijdonk, Martijn PJ Lolkema, Stefan Sleijfer, Emile E Voest, Margreet GEM Ausems and Neeltje Steeghs
Unsolicited findings of next-generation sequencing for tumor analysis within a Dutch consortium: clinical daily practice reconsidered. European Journal of Human Genetics |
Published:
October 24, 2016 |
| Cirkel GA, Weeber F, Bins S, Gadellaa-van Hooijdonk CG, van Werkhoven E, Willems SM, van Stralen M, Veldhuis WB, Ubink I, Steeghs N, de Jonge MJ, Langenberg MH, Schellens JH, Sleijfer S, Lolkema MP, Voest EE
The Time To Progression Ratio: a new individualized volumetric parameter for early detection of clinical benefit of targeted therapies. Annals of Oncology https://www.annalsofoncology.org/article/S0923-7534(19)34751-9/fulltext |
Published:
August 01, 2016 |
| de Leng WW, Gadellaa-van Hooijdonk CG, Barendregt-Smouter FA, Koudijs MJ, Nijman I, Hinrichs JW, Cuppen E, van Lieshout S, Loberg RD, de Jonge M, Voest EE, de Weger RA, Steeghs N, Langenberg MH, Sleijfer S, Willems SM, Lolkema MP
Targeted Next Generation Sequencing as a Reliable Diagnostic Assay for the Detection of Somatic Mutations in Tumours Using Minimal DNA Amounts from Formalin Fixed Paraffin Embedded Material. PLoS One https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0149405 |
Published:
February 26, 2016 |
| Hoogstraat M1, Gadellaa-van Hooijdonk CG, Ubink I, Besselink NJ, Pieterse M, Veldhuis W, van Stralen M, Meijer EF, Willems SM, Hadders MA, Kuilman T, Krijgsman O, Peeper DS, Koudijs MJ, Cuppen E, Voest EE, Lolkema MP
Detailed imaging and genetic analysis reveal a secondary BRAF(L505H) resistance mutation and extensive intrapatient heterogeneity in metastatic BRAF mutant melanoma patients treated with vemurafenib. Pigment Cell Melanoma Res. |
Published:
May 28, 2015 |
| Kuilman T, Velds A, Kemper K, Ranzani M, Bombardelli L, Hoogstraat M, Nevedomskaya E, Xu G, de Ruiter J, Lolkema MP, Ylstra B, Jonkers J, Rottenberg S, Wessels LF, Adams DJ, Peeper DS, Krijgsman O.
CopywriteR: DNA copy number detection from off-target sequence data. Genome Biology https://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0617-1 |
Published:
February 27, 2015 |
| Marlous Hoogstraat, John W J Hinrichs, Nicolle J M Besselink, Joyce H Radersma-van Loon, Carmen M A de Voijs, Ton Peeters, Isaac J Nijman, Roel A de Weger, Emile E Voest, Stefan M Willems, Edwin Cuppen, Marco J Koudijs
Simultaneous detection of clinically relevant mutations and amplifications for cancer diagnostics using Next Generation Sequencing. The Journal of molecular diagnostics |
Published:
January 17, 2015 |
| Beaufort CM, Helmijr JC, Piskorz AM, Hoogstraat M, Ruigrok-Ritstier K, Besselink N, Murtaza M, van IJcken WF, Heine AA, Smid M, Koudijs MJ, Brenton JD, Berns EM, Helleman J.
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes. PLoS One https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103988 |
Published:
September 17, 2014 |
| Hoogstraat M, de Pagter MS, Cirkel GA, van Roosmalen MJ, Harkins TT, Duran K, Kreeftmeijer J, Renkens I, Witteveen PO, Lee CC, Nijman IJ, Guy T, van ’t Slot R, Jonges TN, Lolkema MP, Koudijs MJ, Zweemer RP, Voest EE, Cuppen E, Kloosterman WP.
The genomic and transcriptomic dynamics of treatment-naïve epithelial ovarian cancer. Genome Res. |
Published:
February 24, 2014 |
| Sander Bins, Jan H.M. Schellens, Emile E. Voest, Stefan Sleijfer
Geneesmiddelenonderzoek in de Oncologie, vorderingen in het genoomtijdperk. Nederlands Tijdschrift voor Geneeskunde https://www.ntvg.nl/artikelen/geneesmiddelenonderzoek-de-oncologie |
Published:
February 19, 2014 |
| Geert A Cirkel, Christa G Gadellaa-van Hooijdonk, Marco J Koudijs, Stefan M Willems, Emile E Voest
Tumor heterogeneity and personalized cancer medicine: are we being outnumbered? Future Oncology |
Published:
February 10, 2014 |
| Lolkema MP, Gadellaa-van Hooijdonk CG, Bredenoord AL, Kapitein P, Roach N, Cuppen E, Knoers NV, Voest EE.
Ethical, legal, and counseling challenges surrounding the return of genetic results in oncology. Journal of Clinicla Oncology |
Published:
May 20, 2013 |
| Lips E, Magali M, Mulder L. et al.
Next-generation sequencing to find predictors for chemotherapy response in triple-negative breast cancer. Journal of Clinical Oncology |
Published:
May 20, 2013 |
| Vermaat JS, Nijman IJ, Koudijs MJ, Gerritse FL, Scherer SJ, Mokry M, Roessingh WM, Lansu N, de Bruijn E, van Hillegersberg R, van Diest PJ, Cuppen E, Voest EE.
Primary colorectal cancers and their subsequent hepatic metastases are genetically different: implications for selection of patients for targeted treatment. Clin Cancer Res. |
Published:
February 01, 2012 |
| Harakalova M, Mokry M, Hrdlickova B, Renkens I, Duran K, van Roekel H, Lansu N, van Roosmalen M, de Bruijn E, Nijman IJ, Kloosterman WP, Cuppen E
Multiplexed array-based and in-solution genomic enrichment for flexible and cost-effective targeted next-generation sequencing. Nature Protocols |
Published:
November 03, 2011 |
| Kloosterman WP, Hoogstraat M, Paling O, Tavakoli-Yaraki M, Renkens I, Vermaat JS, van Roosmalen MJ, van Lieshout S, Nijman IJ, Roessingh W, van ’t Slot R, van de Belt J, Guryev V, Koudijs M, Voest E, Cuppen E
Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer. Genome Biology https://genomebiology.biomedcentral.com/articles/10.1186/gb-2011-12-10-r103 |
Published:
October 19, 2011 |
| C.G.M. Gadellaa-van Hooijdonk, M.J. Koudijs, E.P.J.G. Cuppen, P.J. van Diest, J.W.M. Martens, S. Sleijfer, J.H.M. Schellens, E.E. Voest en M.P.J.K. Lolkema
Van DNA-afwijkingen tot therapie: selectie voor geïndividualiseerde kankerbehandeling. Ned. Tijdschr. Oncol. |
Published:
August, 2011 |
| Nijman IJ, Mokry M, van Boxtel R, Toonen P, de Bruijn E, Cuppen E.
Mutation discovery by targeted genomic enrichment of multiplexed barcoded samples. Nature Methods |
Published: October 17, 2010 |
(14-03-2022; versie 22: Publicaties i.h.k.v. CPCT)
| Lindsay Angus, Marcel Smid, Saskia M. Wilting, Manouk K. Bos, Neeltje Steeghs, Inge R.H.M. Konings, Vivianne C.G. Tjan-Heijnen, Johanna M.G.H. Van Riel, Agnes J. Van de Wouw, CPCT Consortium, Edwin Cuppen, Martijn P. Lolkema, Agnes Jager, Stefan Sleijfer, John W. M. Martens.
Genomic alterations associated with estrogen receptor pathway activity in metastatic breast cancer have a differential impact on downstream ER signaling Pudmed: https://pubmed.ncbi.nlm.nih.gov/37686693/
|
Published:
Sep 4, 2023 |
| W S van de Geer WS, Ron H J Mathijssen, Job van Riet, Neeltje Steeghs, Mariette Labots, Carla van Herpen, L A Devriese, Vivianne C G Tjan-Heijnen, Emile E Voest, Stefan Sleijfer, John W M Martens, Edwin Cuppen, Harmen J G van de Werken, Sander Bins.
Identifying somatic changes in drug transporters using whole genome and transcriptome sequencing data of advanced tumors. Pubmed https://pubmed.ncbi.nlm.nih.gov/36621142/ |
Published:
Jan 6, 2023
|
| Melinda A Pruis, F H Groenendijk, KS Badloe, Andrea van Puffelen, Debbie Robbrecht, W N M Dinjens, Stefan Sleijfer, Annemarie C Dingemans, J H von der Thüsen, Paul Roepman, Martijn P J K Lolkema
Personalised selection of experimental treatment in patients with advanced solid cancer is feasible using whole-genome sequencing.
PubMed https://pubmed.ncbi.nlm.nih.gov/35606463/ |
Published:
May 23, 2022
|
| Pauline A J Mendelaar, Debbie Robbrecht, Maud Rijnders, Ronald de Wit, Vanja de Weerd, Teoman Deger, Hans M Westgeest, Maureen J B Aarts, Jens Voortman, John W M Martens, Astrid A M van der Veldt, J Alberto Nakauma-González, Saskia M Wilting, Martijn Lolkema
Genome-wide aneuploidy detected by mFast-SeqS in circulating cell-free DNA is associated with poor response to pembrolizumab in patients with advanced urothelial cancer PubMed |
Published:
February 18, 2022
|
| J Alberto Nakauma-González, Maud Rijnders, Job van Riet, Michiel S van der Heijden, Jens Voortman, Edwin Cuppen, Niven Mehra, Sandra van Wilpe, Sjoukje F Oosting, L Lucia Rijstenberg, Hans M Westgeest, Ellen C Zwarthoff, Ronald de Wit, Astrid A M van der Veldt, Harmen J G van de Werken, Martijn P J Lolkema, Joost L Boormans
Comprehensive Molecular Characterization Reveals Genomic and Transcriptomic Subtypes of Metastatic Urothelial Carcinoma PubMed |
Published:
January 24, 2022
|
| Luuk J Schipper, Kim Monkhorst, Kris G Samsom, Linda J W Bosch, Petur Snaebjornsson, Hester van Boven, Paul Roepman, Lizet E van der Kolk, Winan J van Houdt, Winette T A van der Graaf, Gerrit A Meijer, Emile E Voest
Clinical Impact of Prospective Whole Genome Sequencing in Sarcoma Patients PubMed |
Published:
January 16, 2022 |
| Noori A M Guman, Roos J van Geffen, Frits I Mulder, Thijs F van Haaps, Vahram Hovsepjan, Mariette Labots, Geert A Cirkel, Filip Y F L de Vos, Albert J Ten Tije, Laurens V Beerepoot, Vivianne C G Tjan-Heijnen, Hanneke W M van Laarhoven, Paul Hamberg, Annelie J E Vulink, Maartje Los, Aeilko H Zwinderman, Bart Ferwerda, Martijn P J K Lolkema, Neeltje Steeghs, Harry R Büller, Pieter W Kamphuisen, Nick van Es
Evaluation of the Khorana, PROTECHT, and 5-SNP scores for prediction of venous thromboembolism in patients with cancer PubMed |
Published:
December 19, 2021
|
| Joris van de Haar, Louisa R Hoes, Paul Roepman, Martijn P Lolkema, Henk M W Verheul, Hans Gelderblom, Adrianus J de Langen, Egbert F Smit, Edwin Cuppen, Lodewyk F A Wessels, Emile E Voest
Limited evolution of the actionable metastatic cancer genome under therapeutic pressure Nat Med |
Published:
September 27, 2021 |
| Job van Riet, Harmen J. G. van de Werken, Edwin Cuppen, Ferry A. L. M. Eskens, Margot Tesselaar, Linde M. van Veenendaal, Heinz-Josef Klümpen, Marcus W. Dercksen, Gerlof D. Valk, Martijn P. Lolkema, Stefan Sleijfer & Bianca Mostert
The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets Nature Communications |
Published:
July 29, 2021 |
| Martijn Simons, Michiel van de Ven, Veerle Coupé, Manuela Joore, Maarten IJzerman, Erik Koffijberg, Geert Frederix, Carin Uyl – De Groot, Edwin Cuppen, Wim van Harten & Valesca Retèl on behalf of the TANGO consortium
Early technology assessment of using whole genome sequencing in personalised oncology Expert Rev Pharmacoeconomics & Outcome Res https://www.tandfonline.com/doi/full/10.1080/14737167.2021.1917386 |
Published:
April 29, 2021 |
| Pauline A.J. Mendelaar, Marcel Smid, Job van Riet, Lindsay Angus, Mariette Labots, Neeltje Steeghs, Mathijs P. Hendriks, Geert A. Cirkel, Johan M. van Rooijen, Albert J. Ten Tije, CPCT Consortium, Martijn P.J.K. Lolkema, Edwin Cuppen, Stefan Sleijfer, John W.M. Martens & Saskia M. Wilting
Whole genome sequencing of metastatic CRC reveals prior treatment effects, metastasis-specific features, and potential clinical actionability Nature Communications |
Published:
January 25, 2021 |
| Luan Nguyen, John W.M. Martens, Arne Van Hoeck & Edwin Cuppen
Pan-cancer landscape of homologous recombination deficiency
Nature Communications |
Published:
November 04, 2020 |
| Martijn Simons, Bram Ramaekers, Andrea Peeters, Joanne Mankor, Marthe Paats, Joachim Aerts, Wim van Harten, Valesca Retèl, Manuela Joore
Observed versus modelled lifetime overall survival of targeted therapies and immunotherapies for advanced non-small cell lung cancer patients – A systematic review.
Critical Reviews in Oncology/Hematology https://www.sciencedirect.com/science/article/pii/S1040842820301736?dgcid=coauthor |
Published:
September 23, 2020 |
| Thomas BK Watkins, Emilia L Lim, Marina Petkovic, Sergi Elizalde, Nicolai J Birkbak, Gareth A Wilson, David A Moore, Eva Grönroos, Andrew Rowan, Sally M Dewhurst, Jonas Demeulemeester, Stefan C Dentro, Stuart Horswell, Lewis Au, Kerstin Haase, Mickael Escudero, Rachel Rosenthal, Maise Al Bakir, Hang Xu, Kevin Litchfield, Wei Ting Lu, Thanos P Mourikis, Michelle Dietzen, Lavinia Spain, George D Cresswell, Dhruva Biswas, Philippe Lamy, Iver Nordentoft, Katja Harbst, Francesc Castro-Giner, Lucy R Yates, Franco Caramia, Fanny Jaulin, Cécile Vicier, Ian PM Tomlinson, Priscilla K Brastianos, Raymond J Cho, Boris C Bastian, Lars Dyrskjøt, Göran B Jönsson, Peter Savas, Sherene Loi, Peter J Campbell, Fabrice Andre, Nicholas M Luscombe, Neeltje Steeghs, Vivianne CG Tjan-Heijnen, Zoltan Szallasi, Samra Turajlic, Mariam Jamal-Hanjani, Peter Van Loo, Samuel F Bakhoum, Roland F Schwarz, Nicholas McGranahan, Charles Swanton
Pervasive Chromosomal Instability and Karyotype Order In Tumour Evolution
Nature |
Published:
September 02, 2020 |
| Cayetano Pleguezuelos-Manzano, Jens Puschhof, Axel Rosendahl Huber, Arne van Hoeck, Henry M. Wood, Jason Nomburg, Carino Gurjao, Freek Manders, Guillaume Dalmasso, Paul B. Stege, Fernanda L. Paganelli, Maarten H. Geurts, Joep Beumer, Tomohiro Mizutani, Reinier van der Linden, Stefan van Elst, Genomics England Research Consortium, Janetta Top, Rob J.L. Willems, Marios Giannakis, Richard Bonnet, Phil Quirke, Matthew Meyerson, Edwin Cuppen, Ruben van Boxtel, Hans Clevers
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli.
Nature |
Published:
February 27, 2020 |
| Joanne M. Mankor, Marthe S. Paats, Floris H. Groenendijk, Paul Roepman, Winand N. M. Dinjens, Hendrikus J. Dubbink, Stefan Sleijfer, CPCT Consortium, Edwin Cuppen & Martijn P.J.K. Lolkema
Impact of panel design and cut-off on tumour mutational burden assessment in metastatic solid tumour samples
British journal of cancer |
Published:
February 25, 2020 |
| Wei Jiao, Gurnit Atwal, Paz Polak, Rosa Karlic, Edwin Cuppen, Alexandra Danyi, Jeroen de Ridder, Carla van Herpen, Martijn P Lolkema, Neeltje Steeghs, Gad Getz, Quaid D Morris, Lincoln D. Stein, PCAWG Pathology & Clinical Correlates Working Grp, ICGC/TCGA Pan-cancer Analysis of Whole Genomes Net
A deep learning system can accurately classify primary and metastatic cancers based on patterns of passenger mutations.
Nature Communications |
Published:
February 05, 2020 |
| Lisanne F. van Dessel, Job van Riet, Minke Smits, Yanyun Zhu, Paul Hamberg, Michiel S. van der Heijden, Andries M. Bergman, Inge M. van Oort, Ronald de Wit, Emile E. Voest, Neeltje Steeghs, Takafumi N. Yamaguchi, Julie Livingstone, Paul C. Boutros, John W.M. Martens, Stefan Sleijfer, Edwin Cuppen, Wilbert Zwart, Harmen J.G. van de Werken, Niven Mehra & Martijn P. Lolkema
The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact.
Nature Commununications |
Published:
November 20, 2019 |
| Oriol Pich, Ferran Muiños, Martijn Paul Lolkema, Neeltje Steeghs, Abel Gonzalez-Perez, Nuria Lopez-Bigas
The mutational footprints of cancer therapies. Nature Genetics |
Published:
November 18, 2019 |
| Peter Priestley, Jonathan Baber, Martijn P. Lolkema, Neeltje Steeghs, Ewart de Bruijn, Charles Shale, Korneel Duyvesteyn, Susan Haidari, Arne van Hoeck, Wendy Onstenk, Paul Roepman, Mircea Voda, Haiko J. Bloemendal, Vivianne C. G. Tjan-Heijnen, Carla M. L. van Herpen, Mariette Labots, Petronella O. Witteveen, Egbert F. Smit, Stefan Sleijfer, Emile E. Voest & Edwin Cuppen
Pan-cancer whole-genome analyses of metastatic solid tumors.
Nature https://www.nature.com/articles/s41586-019-1689-y (October 23, 2020) https://www.biorxiv.org/content/10.1101/2020.01.13.905026v2 (June 19, 2020) |
Published:
October 23, 2019 |
| Christensen S, Van der Roest B, Besselink N, Janssen R, Boymans S, Martens JWM, Yaspo ML, Priestley P, Kuijk E, Cuppen E, Van Hoeck A.
5-Fluorouracil treatment induces characteristic T>G mutations in human cancer.
Nature Communications |
Published:
October 08, 2019 |
| Lindsay Angus, Marcel Smid, Saskia M. Wilting, Job van Riet, Arne Van Hoeck, Luan Nguyen, Serena Nik-Zainal, Tessa G. Steenbruggen, Vivianne C.G. Tjan-Heijnen, Mariette Labots, Johanna M.G.H. van Riel, Haiko J. Bloemendal, Neeltje Steeghs, Martijn P. Lolkema, Emile E. Voest, Harmen J.G. van de Werken, Agnes Jager, Edwin Cuppen, Stefan Sleijfer and John W.M. Martens
The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies.
Nature Genetics |
Published:
September 30, 2019 |
| D.L. van der Velden, L.R. Hoes, H. van der Wijngaart, J.M. van Berge Henegouwen, E. van Werkhoven, P. Roepman, R.L. Schilsky, W.W.J. de Leng, A.D.R. Huitema, B. Nuijen, P.M. Nederlof, C.M.L. van Herpen, D.J.A. de Groot, L.A. Devriese, A. Hoeben, M.J.A. de Jonge, M. Chalabi, E.F. Smit, A.J. de Langen, N. Mehra, M. Labots, E. Kapiteijn, S. Sleijfer, E. Cuppen, H.M.W. Verheul, H. Gelderblom and E.E. Voest
The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs.
Nature |
Published:
September 30, 2019 |
| Daniel L. Cameron, Jonathan Baber, Charles Shale, Anthony T. Papenfuss, Jose Espejo Valle-Inclan, Nicolle Besselink, Edwin Cuppen, Peter Priestley
GRIDSS, PURPLE, LINX: Unscrambling the tumor genome via integrated analysis of structural variation and copy number. bioRxiv 781013 |
Published:
September 25, 2019 |
| Ausems MGEM, Oosterwijk JC, Nielsen M, Lolkema MP, Hoogerbrugge N, Ligtenberg MJL.
Genetic testing in patients with cancer, new developments.
Ned Tijdschr Geneeskd. |
Published:
May 20, 2019 |
| Giesbertz NAA, van Harten MH, Bredenoord AL.
A duty of recontact in genetics: context matters.
Nature Reviews Genetics |
Published:
April 01, 2019 |
| Kirsten Kübler, Rosa Karlić, Nicholas J. Haradhvala, Kyungsik Ha, Jaegil Kim, Maja Kuzman, Wei Jiao, Sitanshu Gakkhar, Kent W. Mouw, Lior Z. Braunstein, Olivier Elemento, Andrew V. Biankin, Ilse Rooman, Mendy Miller, Wouter R. Karthaus, Christopher D. Nogiec, Edouard Juvenson, Edward Curry, Mari Mino- Kenudson, Leif W. Ellisen, Robert Brown, Alexander Gusev, Cristian Tomasetti, Martijn P. Lolkema, Neeltje Steeghs, Carla van Herpen, Hong-Gee Kim, Hwajin Lee, Kristian Vlahoviček, Bradley E. Bernstein, Charles L. Sawyers, Katherine A. Hoadley, Edwin Cuppen, Amnon Koren, Peter F. Arndt, David N. Louis, Lincoln D. Stein, William D. Foulkes, Paz Polak, Gad Getz, on behalf of the PCAWG Pathology and Clinical Correlates Working Group, and the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Network
Tumor mutational landscape is a record of the pre-malignant state
bioRxiv 517565 |
Published:
January 11, 2019 |
| Bijlsma RM, Wouters RHP, Wessels H, May AM, Ausems MGEM, Voest EE, Bredenoord AL.
Managing unsolicited findings in genomics: A qualitative interview study with cancer patients.
Psychooncology https://pubmed.ncbi.nlm.nih.gov/29471587/ |
Published:
February 22, 2018 |
| Bijlsma RM, Wessels H, Wouters RHP, May AM, Ausems MGEM, Voest EE, Bredenoord AL.
Cancer patients’ intentions towards receiving unsolicited genetic information obtained using next-generation sequencing.
Fam Cancer https://pubmed.ncbi.nlm.nih.gov/28852913/ |
Published:
April 17, 2018 |
| Weeber F, Cirkel GA, Hoogstraat M, Bins S, Gadellaa-van Hooijdonk CGM, Ooft S, van Werkhoven E, Willems SM, van Stralen M, Veldhuis WB, Besselink NJM, Horlings HM, Steeghs N, de Jonge MJ, Langenberg MHG, Wessels LFA, Cuppen EPJG, Schellens JH, Sleijfer S, Lolkema MP, Voest EE.
Predicting clinical benefit from everolimus in patients with advanced solid tumors, the CPCT-03 study.
Oncotarget https://pubmed.ncbi.nlm.nih.gov/28903445/ |
Published:
March 8, 2017 |
| Bins S, Cirkel GA, Gadellaa-van Hooijdonk CG, Weeber F, Nijman IJ, Bruggink AH, van Diest PJ, Willems SM, Veldhuis WB, van den Heuvel MM, de Knegt RJ, Koudijs MJ, van Werkhoven E, Mathijssen RH, Cuppen E, Sleijfer S, Schellens JH, Voest EE, Langenberg MH, de Jonge MJ, Steeghs N, Lolkema MP.
Implementation of a Multicenter Biobanking Collaboration for Next-Generation Sequencing-Based Biomarker Discovery Based on Fresh Frozen Pretreatment Tumor Tissue Biopsies.
The Oncologist https://theoncologist.onlinelibrary.wiley.com/doi/full/10.1634/theoncologist.2016-0085 |
Published:
January 17, 2017 |
| Rhodé M Bijlsma, Annelien L Bredenoord, Christa G Gadellaa-Hooijdonk, Martijn PJ Lolkema, Stefan Sleijfer, Emile E Voest, Margreet GEM Ausems and Neeltje Steeghs
Unsolicited findings of next-generation sequencing for tumor analysis within a Dutch consortium: clinical daily practice reconsidered.
European Journal of Human Genetics |
Published:
October 24, 2016 |
| Cirkel GA, Weeber F, Bins S, Gadellaa-van Hooijdonk CG, van Werkhoven E, Willems SM, van Stralen M, Veldhuis WB, Ubink I, Steeghs N, de Jonge MJ, Langenberg MH, Schellens JH, Sleijfer S, Lolkema MP, Voest EE
The Time To Progression Ratio: a new individualized volumetric parameter for early detection of clinical benefit of targeted therapies.
Annals of Oncology https://www.annalsofoncology.org/article/S0923-7534(19)34751-9/fulltext |
Published:
August 01, 2016 |
| de Leng WW, Gadellaa-van Hooijdonk CG, Barendregt-Smouter FA, Koudijs MJ, Nijman I, Hinrichs JW, Cuppen E, van Lieshout S, Loberg RD, de Jonge M, Voest EE, de Weger RA, Steeghs N, Langenberg MH, Sleijfer S, Willems SM, Lolkema MP
Targeted Next Generation Sequencing as a Reliable Diagnostic Assay for the Detection of Somatic Mutations in Tumours Using Minimal DNA Amounts from Formalin Fixed Paraffin Embedded Material.
PLoS One https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0149405 |
Published:
February 26, 2016 |
| Hoogstraat M1, Gadellaa-van Hooijdonk CG, Ubink I, Besselink NJ, Pieterse M, Veldhuis W, van Stralen M, Meijer EF, Willems SM, Hadders MA, Kuilman T, Krijgsman O, Peeper DS, Koudijs MJ, Cuppen E, Voest EE, Lolkema MP
Detailed imaging and genetic analysis reveal a secondary BRAF(L505H) resistance mutation and extensive intrapatient heterogeneity in metastatic BRAF mutant melanoma patients treated with vemurafenib.
Pigment Cell Melanoma Res. |
Published:
May 28, 2015 |
| Kuilman T, Velds A, Kemper K, Ranzani M, Bombardelli L, Hoogstraat M, Nevedomskaya E, Xu G, de Ruiter J, Lolkema MP, Ylstra B, Jonkers J, Rottenberg S, Wessels LF, Adams DJ, Peeper DS, Krijgsman O.
CopywriteR: DNA copy number detection from off-target sequence data.
Genome Biology https://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0617-1 |
Published:
February 27, 2015 |
| Marlous Hoogstraat, John W J Hinrichs, Nicolle J M Besselink, Joyce H Radersma-van Loon, Carmen M A de Voijs, Ton Peeters, Isaac J Nijman, Roel A de Weger, Emile E Voest, Stefan M Willems, Edwin Cuppen, Marco J Koudijs
Simultaneous detection of clinically relevant mutations and amplifications for cancer diagnostics using Next Generation Sequencing.
The Journal of molecular diagnostics |
Published:
January 17, 2015 |
| Beaufort CM, Helmijr JC, Piskorz AM, Hoogstraat M, Ruigrok-Ritstier K, Besselink N, Murtaza M, van IJcken WF, Heine AA, Smid M, Koudijs MJ, Brenton JD, Berns EM, Helleman J.
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
PLoS One https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103988 |
Published:
September 17, 2014 |
| Hoogstraat M, de Pagter MS, Cirkel GA, van Roosmalen MJ, Harkins TT, Duran K, Kreeftmeijer J, Renkens I, Witteveen PO, Lee CC, Nijman IJ, Guy T, van ’t Slot R, Jonges TN, Lolkema MP, Koudijs MJ, Zweemer RP, Voest EE, Cuppen E, Kloosterman WP.
The genomic and transcriptomic dynamics of treatment-naïve epithelial ovarian cancer.
Genome Res. |
Published:
February 24, 2014 |
| Sander Bins, Jan H.M. Schellens, Emile E. Voest, Stefan Sleijfer
Geneesmiddelenonderzoek in de Oncologie, vorderingen in het genoomtijdperk.
Nederlands Tijdschrift voor Geneeskunde https://www.ntvg.nl/artikelen/geneesmiddelenonderzoek-de-oncologie |
Published:
February 19, 2014 |
| Geert A Cirkel, Christa G Gadellaa-van Hooijdonk, Marco J Koudijs, Stefan M Willems, Emile E Voest
Tumor heterogeneity and personalized cancer medicine: are we being outnumbered?
Future Oncology |
Published:
February 10, 2014 |
| Lolkema MP, Gadellaa-van Hooijdonk CG, Bredenoord AL, Kapitein P, Roach N, Cuppen E, Knoers NV, Voest EE.
Ethical, legal, and counseling challenges surrounding the return of genetic results in oncology.
Journal of Clinicla Oncology |
Published:
May 20, 2013 |
| Lips E, Magali M, Mulder L. et al.
Next-generation sequencing to find predictors for chemotherapy response in triple-negative breast cancer.
Journal of Clinical Oncology |
Published:
May 20, 2013 |
| Vermaat JS, Nijman IJ, Koudijs MJ, Gerritse FL, Scherer SJ, Mokry M, Roessingh WM, Lansu N, de Bruijn E, van Hillegersberg R, van Diest PJ, Cuppen E, Voest EE.
Primary colorectal cancers and their subsequent hepatic metastases are genetically different: implications for selection of patients for targeted treatment.
Clin Cancer Res. |
Published:
February 01, 2012 |
| Harakalova M, Mokry M, Hrdlickova B, Renkens I, Duran K, van Roekel H, Lansu N, van Roosmalen M, de Bruijn E, Nijman IJ, Kloosterman WP, Cuppen E
Multiplexed array-based and in-solution genomic enrichment for flexible and cost-effective targeted next-generation sequencing.
Nature Protocols |
Published:
November 03, 2011 |
| Kloosterman WP, Hoogstraat M, Paling O, Tavakoli-Yaraki M, Renkens I, Vermaat JS, van Roosmalen MJ, van Lieshout S, Nijman IJ, Roessingh W, van ’t Slot R, van de Belt J, Guryev V, Koudijs M, Voest E, Cuppen E
Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer.
Genome Biology https://genomebiology.biomedcentral.com/articles/10.1186/gb-2011-12-10-r103 |
Published:
October 19, 2011 |
| C.G.M. Gadellaa-van Hooijdonk, M.J. Koudijs, E.P.J.G. Cuppen, P.J. van Diest, J.W.M. Martens, S. Sleijfer, J.H.M. Schellens, E.E. Voest en M.P.J.K. Lolkema
Van DNA-afwijkingen tot therapie: selectie voor geïndividualiseerde kankerbehandeling.
Ned. Tijdschr. Oncol. |
Published:
August, 2011 |
| Nijman IJ, Mokry M, van Boxtel R, Toonen P, de Bruijn E, Cuppen E.
Mutation discovery by targeted genomic enrichment of multiplexed barcoded samples.
Nature Methods |
Published: October 17, 2010 |