A selection of leading scientific publications
A chronological overview of top publications from CPCT studies and partner projects.
20264
- DRUP·2026
BRAFV600E-mutated central nervous system tumors benefit from treatment with dabrafenib plus trametinib: Results from the Drug Rediscovery Protocol
Haj Mohammad SF, et al. European Journal of Cancer.
Read publication → - DRUP·2026
Olaparib for patients with tumors harboring alterations in homologous recombination repair genes: Results from the Drug Rediscovery Protocol
Spiekman IAC, et al. International Journal of Cancer.
Read publication → - PRIME-ROSE·2026
Procedures of data merging in precision cancer medicine: the PRIME-ROSE project
van der Pol H, et al. Acta Oncologica.
Read publication → - DRUP·2026
Prospective evaluation of genomics-guided off-label treatment
Verkerk K, et al. Nature.
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20253
- DRUP·2025
Checkpoint Blockade Combinations in Tumor Mutational Burden/Load-High Tumors: Insights from the Atezolizumab + Bevacizumab and Nivolumab + Ipilimumab Cohorts in the Drug Rediscovery Protocol
Verkerk K, et al. Clinical Cancer Research.
Read publication → - PRIME-ROSE·2025
Accelerating precision oncology by converging pragmatic trials and real-world evidence
Taskén K, Mahon P. Nature Reviews Drug Discovery.
Read publication → - The Dark Genome (BEACON)·2025
Regulatory grammar in human promoters uncovered by MPRA-based deep learning
BEACON consortium Nature.
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20249
- DRUP·2024
Safety, Efficacy, and Biomarker Analysis of Crizotinib in MET-Mutated Non-Small Cell Lung Cancer: Results from the Drug Rediscovery Protocol
Verkerk K, et al. Clinical Cancer Research.
Read publication → - DRUP·2024
The Innate Immune Landscape of dMMR/MSI Cancers Predicts the Outcome of Nivolumab Treatment: Results from the Drug Rediscovery Protocol
Zeverijn LJ, et al. Clinical Cancer Research.
Read publication → - DRUP·2024
Efficacy of Pembrolizumab and Biomarker Analysis in Patients with WGS-Based Intermediate to High Tumor Mutational Load: Results from the Drug Rediscovery Protocol
Geurts BS, et al. Clinical Cancer Research.
Read publication → - PRIME-ROSE·2024
PCM4EU and PRIME-ROSE: Collaboration for implementation of precision cancer medicine in Europe
Taskén K, et al. Acta Oncologica.
Read publication → - DRUP·2024
Efficacy and Safety of Panitumumab in Patients With RAF/RAS-Wild-Type Glioblastoma: Results From the Drug Rediscovery Protocol
Spiekman IAC, et al. The Oncologist.
Read publication → - DRUP·2024
Trastuzumab plus pertuzumab for HER2-amplified advanced colorectal cancer: Results from the Drug Rediscovery Protocol (DRUP)
Spiekman IAC, et al. European Journal of Cancer.
Read publication → - Immunotherapy in lung cancer·2024
Combining Genomic Biomarkers to Guide Immunotherapy in Non-Small Cell Lung Cancer
van de Haar J, et al. Clinical Cancer Research.
Read publication → - DAP / cemiplimab·2024
Cemiplimab in locally advanced or metastatic cutaneous squamous cell carcinoma: prospective real-world data from the DRUG Access Protocol
Verkerk K, et al. The Lancet Regional Health – Europe.
Read publication → - Microbiome·2024
A pan-cancer analysis of the microbiome in metastatic cancer
Battaglia TW, et al. Cell.
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20233
- DRUP·2023
Limited clinical activity of palbociclib and ribociclib monotherapy in advanced cancers with cyclin D-CDK4/6 pathway alterations in the Dutch DRUP and Australian MoST trials
Zeverijn LJ, et al. International Journal of Cancer.
Read publication → - A biomarker for chemotherapy·2023
Codon-specific KRAS mutations predict survival benefit of trifluridine/tipiracil in metastatic colorectal cancer
van de Haar J, et al. Nature Medicine.
Read publication → - Immunotherapy in colorectal cancer·2023
Gamma-delta T cells are effectors of immunotherapy in cancers with HLA class I defects
de Vries NL, et al. Nature.
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20221
- DAP·2022
Harmonising patient-access programmes: the Dutch DRUG Access Protocol platform
Zeverijn LJ, et al. The Lancet Oncology.
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20211
- Actionable genome·2021
Limited evolution of the actionable metastatic cancer genome under therapeutic pressure
van de Haar J, et al. Nature Medicine.
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20192
- Hartwig DB·2019
Pan-cancer whole-genome analyses of metastatic solid tumours
Priestley P, et al. Nature.
Read publication → - DRUP·2019
The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs
van der Velden DL, et al. Nature.
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